Kawada J, Okita M, Nishida M, Yoshimura Y, Toyooka K, Kubota S
J Endocrinol. 1987 Mar;112(3):375-8. doi: 10.1677/joe.0.1120375.
Ethylidene glucose (4,6-O-ethylidene glucose; EG) is known to bind the outer surface of the glucose transporter in the membranes of human erythrocytes and other mammalian cells. If a glucose transport system is present on pancreatic beta cells and recognizes the glucose moiety of streptozotocin (STZ), EG should protect beta cells from the cytotoxicity of STZ when it is administered with STZ. This possibility was examined in in-vivo experiments in rats. When EG and STZ were injected into rats together the animals did not become diabetic, as judged by their blood glucose levels, response in a glucose-tolerance test, and insulin secretion in response to feeding. These results suggest that there is a glucose transporter present in beta cells and also the transport of streptozotocin into beta cells through this system.
亚乙基葡萄糖（4,6-O-亚乙基葡萄糖；EG）已知可结合人红细胞和其他哺乳动物细胞膜中葡萄糖转运蛋白的外表面。如果胰腺β细胞上存在葡萄糖转运系统并能识别链脲佐菌素（STZ）的葡萄糖部分，那么当EG与STZ一起给药时，EG应该能保护β细胞免受STZ的细胞毒性作用。在大鼠体内实验中对这种可能性进行了研究。当将EG和STZ一起注射到大鼠体内时，根据它们的血糖水平、葡萄糖耐量试验反应以及进食后的胰岛素分泌情况判断，这些动物并未患糖尿病。这些结果表明β细胞中存在葡萄糖转运蛋白，并且STZ可通过该系统转运进入β细胞。
