Kuchel O, Debinski W, Racz K, Buu N T, Garcia R, Cusson J R, Larochelle P, Cantin M, Genest J
Life Sci. 1987 Apr 20;40(16):1545-51. doi: 10.1016/0024-3205(87)90119-6.
The sympathetic nervous system and atrial natriuretic factor (ANF) are intimately involved in sodium, volume and blood pressure homeostasis, particularly in response to volume and pressure overloads. Although rapid progress in this field indicates several levels of interaction between both systems, the role of sympathetic nervous activity (SNA) in ANF release remains a controversial topic. There is growing evidence that ANF is an inhibitory modulator of sympathetic outflow (which in turn, may contribute to ANF's effect) and, vice-versa, SNA attenuates the target actions of ANF. Compensatory sympathetic reactions to changes induced by ANF may also have an overriding influence on its target actions. Dopamine appears to play a special role in these interactions. It is not only a precursor of norepinephrine but probably fulfills an independent function in the regulation of salt balance, similar in many respects to that of ANF.
交感神经系统和心房利钠因子（ANF）密切参与钠、容量和血压的稳态调节，尤其是在应对容量和压力过载时。尽管该领域的快速进展表明这两个系统之间存在多个层面的相互作用，但交感神经活动（SNA）在ANF释放中的作用仍是一个有争议的话题。越来越多的证据表明，ANF是交感神经传出的抑制性调节因子（反过来，这可能有助于ANF发挥作用），反之，SNA会减弱ANF的靶作用。对ANF诱导的变化的代偿性交感反应也可能对其靶作用产生首要影响。多巴胺似乎在这些相互作用中发挥特殊作用。它不仅是去甲肾上腺素的前体，而且可能在盐平衡调节中发挥独立作用，在许多方面与ANF相似。
