Kreiberg Michael, Bandak Mikkel, Lauritsen Jakob, Skøtt Julie Wang, Johansen Nanna Borup, Agerbaek Mads, Holm Niels Vilstrup, Johansen Christoffer, Daugaard Gedske
Department of Oncology 5073, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Research Centre for Prevention and Health, Centre for Health, Glostrup, Denmark.
Front Oncol. 2018 Feb 21;8:37. doi: 10.3389/fonc.2018.00037. eCollection 2018.
The cohort was set up in order to analyze late effects in long-term testicular cancer survivors (TCS) and to contribute to the design of future follow-up programs addressing and potentially preventing late effects. Data for this cross-sectional study were collected between January 1, 2014, and December 31, 2016, among living Danish TCS and 60% agreed to participate in the cohort ( = 2,572). Mean time since testicular cancer (TC) diagnosis was 18 years (range 7-33) and mean age of participants was 53 years (range 25-95). Data consist of results of a questionnaire with patient reported outcomes which covers a broad range of items on late-effects. The study also included data obtained through linkages to Danish registries, a biobank, and clinical data from hospital files and pathology reports originating from the Danish Testicular Cancer Database (DaTeCa). The treatment during the observation period has been nearly the same for all stages of TC and is in agreement with today's standard treatment, this allows for interesting analysis with a wide timespan. We have extensive data on non-responders and are able to validate our study findings. Data from a Danish reference population ( = 162,283) allow us to compare our findings with a Danish background population. The cohort can easily be extended to access more outcomes, or include new TCS. A limitation of the present study is the cross-sectional design and despite the large sample size, The Danish Testicular Cancer Late Treatment Effects Cohort (DaTeCa-LATE) lacks statistical power to study very rare late effects. Since it was voluntary to participate in the study we have some selection bias, for instance, we lack responders who were not in a paired relationship, but we would still argue that this cohort of TCSs is representative for TCSs in Denmark.
Researches interested in collaboration with the DaTeCa-LATE study group please contact Professor Gedske Daugaard kirsten.gedske.daugaard@regionh.dk.
设立该队列是为了分析长期睾丸癌幸存者（TCS）的晚期效应，并为未来针对和潜在预防晚期效应的随访计划设计做出贡献。这项横断面研究的数据于2014年1月1日至2016年12月31日期间收集，对象为在世的丹麦TCS，60%同意参与该队列（n = 2572）。自睾丸癌（TC）诊断后的平均时间为18年（范围7 - 33年），参与者的平均年龄为53岁（范围25 - 95岁）。数据包括一份问卷的结果，其中有患者报告的结局，涵盖了关于晚期效应的广泛项目。该研究还包括通过与丹麦登记处、生物样本库以及来自丹麦睾丸癌数据库（DaTeCa）的医院档案和病理报告中的临床数据建立联系而获得的数据。观察期内TC各阶段的治疗情况几乎相同，且与当今的标准治疗一致，这使得能够在较宽的时间跨度内进行有趣的分析。我们有关于无应答者的广泛数据，并且能够验证我们的研究结果。来自丹麦参考人群（n = 162283）的数据使我们能够将研究结果与丹麦背景人群进行比较。该队列可以很容易地扩展以获取更多结局，或纳入新的TCS。本研究的一个局限性是横断面设计，尽管样本量很大，但丹麦睾丸癌晚期治疗效应队列（DaTeCa - LATE）缺乏研究非常罕见的晚期效应的统计效力。由于参与研究是自愿的，我们存在一些选择偏倚，例如，我们缺乏非配对关系的应答者，但我们仍然认为这个TCS队列代表了丹麦的TCS。
有兴趣与DaTeCa - LATE研究组合作的研究人员请联系Gedske Daugaard教授，邮箱为kirsten.gedske.daugaard@regionh.dk。
