Tang Hui, Zhang Jinjin, Guo Qiang
Faculty of Medicine, Kunming University of Science and Technology; Institute of Basic Medical Sciences, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650504, Yunnan, China.
Faculty of Medicine, Kunming University of Science and Technology, Kunming 650504, Yunnan, China.
J Cancer Res Ther. 2018 Jan;14(1):6-11. doi: 10.4103/jcrt.JCRT_701_17.
Transcription factor forkhead box Q1 (FOXQ1), a member of the forkhead box superfamily, has been involved in various biological processes and plays important roles in tumor initiation and progression. The FOXQ1 protein activated transcription of target genes directly by binding to the promoters of target genes or indirectly by interacting with other transcription factors. FOXQ1 affected the initiation, progression, invasion, and metastasis of many kinds of tumor by promoting the epithelial-mesenchymal transition, regulating cell cycle, promoting cell proliferation, regulating senescence-associated inflammation, and activating many cellular signal pathways. In this review, we have focused on the possible molecular mechanisms for FOXQ1 gene in tumor initiation and progression. Medline literature review related to this subject was performed by the electronically retrieval with the keywords "forkhead box Q1" and "tumor" on PubMed for including previous publications, and then, it further reviewed reference articles on the biological function of FOXQ1 gene and target genes transcription directly regulated by FOXQ1.
转录因子叉头框Q1（FOXQ1）是叉头框超家族的成员之一，参与多种生物学过程，在肿瘤的发生和发展中起重要作用。FOXQ1蛋白通过直接结合靶基因的启动子或间接与其他转录因子相互作用来激活靶基因的转录。FOXQ1通过促进上皮-间质转化、调节细胞周期、促进细胞增殖、调节衰老相关炎症以及激活多种细胞信号通路，影响多种肿瘤的发生、发展、侵袭和转移。在本综述中，我们重点关注了FOXQ1基因在肿瘤发生和发展中的可能分子机制。通过在PubMed上以“叉头框Q1”和“肿瘤”为关键词进行电子检索，对与该主题相关的Medline文献进行了综述，以纳入以前的出版物，然后进一步综述了关于FOXQ1基因生物学功能以及由FOXQ1直接调控的靶基因转录的参考文献。
