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在晚期帕金森病中使用管饲法和左旋多巴-卡比多巴肠凝胶

Using tube feeding and levodopa-carbidopa intestinal gel application in advanced Parkinson's disease.

作者信息

Lex Katharina Maria, Kundt Firuzan Sari, Lorenzl Stefan

机构信息

Research Associate, Institute for Nursing Science and Research, Medical University, Salzburg, Austria.

Professor for Interdisciplinary Research in Palliative Care, Institute for Nursing Science and Research, Medical University, Salzburg, Austria.

出版信息

Br J Nurs. 2018 Mar 8;27(5):259-262. doi: 10.12968/bjon.2018.27.5.259.

DOI:10.12968/bjon.2018.27.5.259
PMID:29517331
Abstract

The inability to achieve adequate nutrition and weight loss are serious problems for patients with advanced Parkinson's disease (PD). To ensure the optimal intake of nutrition and fluids and to administer levodopa-carbidopa intestinal gel (LCIG) (which patients need to increase or maintain their mobility as long as possible), different artificial feeding tubes can be used. Although percutaneous endoscopic gastrostomy (PEG) tubes are frequently used in medical practice, there is little research that addresses key questions, including if and when to administer artificial fluids, nutrition and/or LCIG via tubes. Weight gain through tube feeding is only possible for some patients; nurses should keep in mind that tube insertion and feeding may lead to frequent adverse events. Administering LCIG via tubes is usually advisable as it seems to enhance patients' mobility and therefore has positive outcomes in terms of the quality of life of patients and their families ( Lim et al, 2015 ). The authors aimed to examine the use and consequences of providing nutrition and LCIG via gastrostomy tubes in PD patients with advanced disease.

摘要

无法获得充足营养和体重减轻是晚期帕金森病(PD)患者面临的严重问题。为确保营养和液体的最佳摄入,并给予左旋多巴-卡比多巴肠凝胶(LCIG)(患者需要该药物来尽可能长时间地增加或维持其活动能力),可使用不同的人工喂养管。尽管经皮内镜下胃造口术(PEG)管在医疗实践中经常使用,但针对关键问题的研究很少,包括是否以及何时通过管道给予人工液体、营养和/或LCIG。只有部分患者通过管饲能够实现体重增加;护士应牢记,插入管道和喂养可能会导致频繁的不良事件。通过管道给予LCIG通常是可取的,因为这似乎能增强患者的活动能力,因此对患者及其家人的生活质量有积极影响(Lim等人,2015年)。作者旨在研究通过胃造口管为晚期PD患者提供营养和LCIG的使用情况及后果。

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引用本文的文献

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J Neural Transm (Vienna). 2023 Nov;130(11):1383-1394. doi: 10.1007/s00702-023-02601-0. Epub 2023 Feb 21.
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Gastrostomy tubes: Fundamentals, periprocedural considerations, and best practices.胃造口管:基础、围手术期注意事项及最佳实践。
World J Gastrointest Surg. 2022 Apr 27;14(4):286-303. doi: 10.4240/wjgs.v14.i4.286.
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Consensus-Based Recommendations for Advance Directives of People with Parkinson's Disease in Regard to Typical Complications by German Movement Disorder Specialists.
德国运动障碍专家关于帕金森病患者针对典型并发症的预先指示的基于共识的建议。
J Clin Med. 2020 Feb 6;9(2):449. doi: 10.3390/jcm9020449.
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Advance Directives of German People with Parkinson's Disease Are Unspecific in regard to Typical Complications.德国帕金森病患者的预先医疗指示在典型并发症方面缺乏特异性。
Parkinsons Dis. 2019 Aug 4;2019:2107821. doi: 10.1155/2019/2107821. eCollection 2019.