Mathonet P Y, Willems S, Ciornohac J F
Service de Chirurgie orthopédique, CHC Liège, Belgique.
Rev Med Liege. 2018 Feb;73(2):56-60.
Bisphosphonates have frequently shown their efficacy in the treatment of osteoporosis, including ibandronate and alendronate. But more and more mention is made in the literature of patients taking a long-term bisphosphonate and undergoing an atypical fracture associated with this therapy. These complications are most often femoral fractures in the proximal part of the femoral diaphysis. We report the case of a 73-year-old patient who had a subtrochanteric pathological fracture after a prolonged intake of alendronate followed by ibandronate.
双膦酸盐已频繁显示出其在治疗骨质疏松症方面的疗效,包括伊班膦酸钠和阿仑膦酸钠。但文献中越来越多地提到长期服用双膦酸盐并出现与此治疗相关的非典型骨折的患者。这些并发症最常见的是股骨干近端的股骨骨折。我们报告了一例73岁患者的病例,该患者在长期服用阿仑膦酸钠后改用伊班膦酸钠,随后发生了转子下病理性骨折。