Ruprechter Gretel, Adrien Maria de Lourdes, Larriestra Alejandro, Meotti Otavio, Batista Chester, Meikle Ana, Noro Mirela
Animal Endocrine and Metabolism Laboratory, Veterinary Faculty, Montevideo, Uruguay.
Health in Livestock Systems Department, Veterinary Faculty, Paysandú, Uruguay.
Res Vet Sci. 2018 Jun;118:191-198. doi: 10.1016/j.rvsc.2018.02.005. Epub 2018 Feb 19.
The predictive values of plasma non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), cholesterol, albumin and calcium to predict risk of peripartum diseases in primiparous (PP) and multiparous (MP) Holstein cows was investigated. Besides it was assessed if the health status interacted with parity on body condition score and metabolic profiles during the transition period. Dairy cows (126 PP and 182 MP) from a commercial dairy free stall herd (loose-housing system) were weekly body condition scored and tail bled for metabolites determination from -3 to +4 weeks relative to calving. Peripartum diseases were diagnosed by a single trained veterinarian, while subclinical diseases (ketosis and hypocalcemia) were diagnosed at the laboratory. Cows were classified as healthy cows, cows with one event, or cows with two clinical events following a prospective observational cohort study, with only healthy cows enrolled at the beginning of the study. The largest incidence was for metritis (26.6%) followed by retained placenta (17.2%) and mastitis (15.2%) with no effect of parity, while subclinical hypocalcemia incidence was greater in MP than PP cows (43% vs 9.5%) respectively. In MP cows albumin concentrations were predictive for metritis at week -2 and for retained placenta at weeks -2 and -1, while cholesterol was predictive for mastitis at week -2, -1 and at calving. The interaction between health status and parity affected all metabolites during the transition period. This study showed a different evolution of metabolic profiles in healthy and sick cows during the transition according to parity, pointing out albumin and cholesterol as diseases predictors before calving.
研究了血浆非酯化脂肪酸（NEFA）、β-羟基丁酸（BHB）、胆固醇、白蛋白和钙对初产（PP）和经产（MP）荷斯坦奶牛围产期疾病风险的预测价值。此外，还评估了健康状况与胎次在过渡期对体况评分和代谢谱的相互作用。来自商业散栏式牛群（自由放养系统）的奶牛（126头初产牛和182头经产牛）在产犊前-3至+4周每周进行体况评分并尾静脉采血以测定代谢产物。围产期疾病由一名经过专门培训的兽医诊断，而亚临床疾病（酮病和低钙血症）在实验室诊断。按照前瞻性观察队列研究，奶牛被分为健康奶牛、发生一次事件的奶牛或发生两次临床事件的奶牛，研究开始时仅纳入健康奶牛。发病率最高的是子宫炎（26.6%），其次是胎衣不下（17.2%）和乳腺炎（15.2%），不受胎次影响，而亚临床低钙血症的发病率经产牛高于初产牛（分别为43%和9.5%）。在经产牛中，白蛋白浓度在-2周时可预测子宫炎，在-2周和-1周时可预测胎衣不下，而胆固醇在-2周、-1周和产犊时可预测乳腺炎。健康状况与胎次之间的相互作用在过渡期影响所有代谢产物。本研究表明，根据胎次不同，健康和患病奶牛在过渡期的代谢谱变化不同，指出白蛋白和胆固醇在产犊前可作为疾病预测指标。
