Koray M, Atalay B, Akgul S, Oguz F S, Mumcu G, Saruhanoglu A
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Istanbul University, Capa, Fatih, Istanbul, Turkey.
Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul University, Capa, Fatih, Istanbul, Turkey.
Niger J Clin Pract. 2018 Mar;21(3):271-275. doi: 10.4103/njcp.njcp_23_17.
Recurrent aphthous stomatitis (RAS) is an inflammatory condition of the oral mucosa. The etiology of RAS remains unclear. Calprotectin is a major cytoplasmic protein contained in granulocytes, monocytes/macrophages and epithelial cells, and its level is increased body fluids in some inflammatory diseases. The aim is to determine the relationship between salivary calprotectin and RAS.
In the cross-sectional study, 67 patients with active lesions of RAS (F/M: 43/24, mean age: 30.27 ± 9.14 years) and 42 healthy controls (HC, F/M: 30/12, 30.54 ± 9.49 years) were included. Calprotectin levels were evaluated in unstimulated whole saliva samples by using the ELISA method in both groups.
Salivary calprotectin levels were significantly higher in RAS group (23.72 ± 4.28 mg/L) compared to the HC group (21.59 ± 4.27 mg/L) (P = 0.013). No significant relationship was found between calprotectin levels and age or gender in both groups (P >0.05).
RAS is a very common inflammatory ulcerative condition of the oral cavity and its etiology is uncertain. Regarded as an inflammatory mechanism, releasing a high level of calprotectin in saliva has been suggested that it may play a role in pathogenesis of RAS.
复发性阿弗他口炎（RAS）是口腔黏膜的一种炎症性疾病。RAS的病因仍不清楚。钙卫蛋白是粒细胞、单核细胞/巨噬细胞和上皮细胞中含有的一种主要细胞质蛋白，在某些炎症性疾病中其在体液中的水平会升高。目的是确定唾液钙卫蛋白与RAS之间的关系。
在这项横断面研究中，纳入了67例有RAS活动病变的患者（男/女：43/24，平均年龄：30.27±9.14岁）和42例健康对照者（HC，男/女：30/12，30.54±9.49岁）。两组均采用ELISA法评估非刺激性全唾液样本中的钙卫蛋白水平。
RAS组的唾液钙卫蛋白水平（23.72±4.28mg/L）显著高于HC组（21.59±4.27mg/L）（P=0.013）。两组中钙卫蛋白水平与年龄或性别均无显著关系（P>0.05）。
RAS是一种非常常见的口腔炎症性溃疡性疾病，其病因尚不确定。作为一种炎症机制，唾液中高水平的钙卫蛋白释放可能在RAS的发病机制中起作用。
