复发性阿弗他口炎的一种新型预后生物标志物：钙卫蛋白。
A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin.
作者信息
Kayabasi S, Kuzucu I
机构信息
Department of ENT, Aksaray University Faculty of Medicine, Turkey.
出版信息
J Laryngol Otol. 2019 Aug;133(8):691-695. doi: 10.1017/S0022215119001440. Epub 2019 Jul 9.
OBJECTIVE
This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis.
METHOD
This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters.
RESULTS
The median calprotectin value of the active lesion group (80.5 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017).
CONCLUSION
In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.
目的
本研究旨在调查复发性阿弗他口炎患者血清钙卫蛋白浓度与口腔溃疡活动度之间是否存在相关性。
方法
这项前瞻性、横断面、历史性队列研究纳入了52例复发性阿弗他口炎患者（26例有活动性病损，26例有非活动性病损）以及27名健康志愿者。对各组之间血清钙卫蛋白水平及其他炎症参数的关系进行统计学评估。
结果
活动性病损组的钙卫蛋白中位数（80.5 ng/ml）显著高于对照组（55.4 ng/ml，p = 0.002）。此外，活动性病损组的钙卫蛋白中位数显著高于非活动性病损组（72.5 ng/ml，p = 0.017）。
结论
在复发性阿弗他口炎且有活动性溃疡病损的患者中，血清钙卫蛋白值可作为炎症可靠且有力的预后标志物。
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