Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands.
Department of Medical Microbiology, University Medical Centre Utrecht, Utrecht, Netherlands.
Nat Rev Immunol. 2018 Jun;18(6):363-373. doi: 10.1038/s41577-018-0001-y.
Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.
幼稚 T 细胞长期以来一直被认为是一种发育上同步的、相当同质和静止的细胞群体，其大小取决于年龄、胸腺输出和先前的感染。然而，越来越多的证据表明，幼稚 T 细胞在表型、功能、动力学和分化状态上是异质的。目前识别幼稚 T 细胞的策略应该进行调整，以考虑到这种异质性。在这里，我们提供了一个幼稚 T 细胞区室的综合、修订视图，并讨论了它对健康衰老、新生儿免疫和造血干细胞移植后 T 细胞重建的影响。
