Vaccine & Infectious Disease Institute, University of Antwerp, Wilrijk.
Department of Mathematics and Statistics, Hasselt University, Diepenbeek, Belgium.
Clin Infect Dis. 2018 Aug 1;67(4):628-638. doi: 10.1093/cid/ciy190.
Enteric fever is a febrile illness, occurring mostly in Asia and Africa, which can present as a severe and possibly fatal disease. Currently, a case fatality rate (CFR) of 1% is assumed when evaluating the global burden of enteric fever. Until now, no meta-analysis has been conducted to summarize mortality from enteric fever. Therefore, we conducted a systematic review and meta-analysis to aggregate all available evidence. We estimated an overall CFR of 2.49% (95% confidence interval, 1.65%-3.75%; n = 44), and a CFR in hospitalized patients of 4.45% (2.85%-6.88%; n = 21 of 44). There was considerably heterogeneity in estimates of the CFR from individual studies. Neither age nor antimicrobial resistance were significant prognostic factors, but limited data were available for these analyses. The combined estimate of the CFR for enteric fever is higher than previously estimated, and the evaluation of prognostic factors, including antimicrobial resistance, urgently requires more data.
肠热病是一种发热性疾病，主要发生在亚洲和非洲，可表现为严重且可能致命的疾病。目前，在评估肠热病的全球负担时，假定病死率（CFR）为 1%。到目前为止，尚无荟萃分析来总结肠热病的死亡率。因此，我们进行了系统评价和荟萃分析，以汇总所有可用证据。我们估计总病死率为 2.49%（95%置信区间，1.65%-3.75%；n = 44），住院患者的病死率为 4.45%（2.85%-6.88%；n = 44 例中的 21 例）。来自个别研究的 CFR 估计存在相当大的异质性。年龄和抗菌药物耐药性均不是重要的预后因素，但这些分析的可用数据有限。肠热病病死率的综合估计值高于之前的估计值，包括抗菌药物耐药性在内的预后因素的评估迫切需要更多的数据。
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