IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia Agraria, Centro di Ricerca Agricoltura e Ambiente (CREA-AA), Via di Corticella 133, 40128 Bologna, Italy.
Molecules. 2018 Mar 9;23(3):624. doi: 10.3390/molecules23030624.
The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive products resulting from enzymatic hydrolysis of glucosinolates (GLs), the most abundant secondary metabolites in the botanical order Brassicales. Although the antimicrobial activity of ITCs against foodborne and plant pathogens has been well documented, little is known about their antimicrobial properties against human pathogens. This review collects studies that focus on this topic. Particular focus will be put on ITCs' antimicrobial properties and their mechanism of action against human pathogens for which the current therapeutic solutions are deficient and therefore of prime importance for public health. Our purpose was the evaluation of the potential use of ITCs to replace or support the common antibiotics. Even though ITCs appear to be effective against the most important human pathogens, including bacteria with resistant phenotypes, the majority of the studies did not show comparable results and thus it is very difficult to compare the antimicrobial activity of the different ITCs. For this reason, a standard method should be used and further studies are needed.
植物源产品作为抗菌剂的应用已经得到了深入研究。异硫氰酸酯（ITCs）是植物门芸苔属中含量最丰富的次生代谢产物硫代葡萄糖苷（GLs）经酶水解产生的生物活性产物。虽然 ITCs 对食源性病原体和植物病原体的抗菌活性已得到充分证实，但对其针对人体病原体的抗菌特性知之甚少。本综述收集了专注于该主题的研究。特别关注的是 ITCs 对人体病原体的抗菌特性及其作用机制，因为针对这些病原体，目前的治疗方法存在不足，因此对公共卫生具有重要意义。我们的目的是评估 ITCs 替代或支持常用抗生素的潜力。尽管 ITCs 似乎对包括具有耐药表型的细菌在内的最重要的人体病原体有效，但大多数研究并未显示出可比的结果，因此很难比较不同 ITCs 的抗菌活性。出于这个原因，应该使用标准方法，并且需要进一步的研究。
