Jones R J, Delamothe A P, Curtis L D, Machin S J, Betteridge D J
Diabet Med. 1985 Mar;2(2):105-9. doi: 10.1111/j.1464-5491.1985.tb00610.x.
Platelet function has been studied in diabetic subjects using a new electronic platelet aggregometer which enables platelet aggregation to be studied in whole blood. This may be a more physiological approach to the assessment of platelet behaviour as centrifugation is avoided and platelets are studied in the presence of other blood elements which may be important modulators of platelet function in vivo. Twenty insulin-dependent diabetic subjects were studied along with 20 age and sex-matched controls. Platelet aggregation to collagen (1 microgram/ml) and arachidonic acid (1 mM) was significantly increased in the diabetic group. In addition the sensitivity of diabetic platelets to the antiaggregatory effects of prostacyclin was significantly reduced. A significant inverse correlation was found between platelet sensitivity to prostacyclin and glycosylated haemoglobin concentration in the diabetic group. It is unlikely that the platelet abnormalities in this diabetic group are due to underlying vascular disease as none of the patients had evidence of diabetic complications. These findings may have important implications for the development of vascular disease in diabetics.
利用一种新型电子血小板聚集仪对糖尿病患者的血小板功能进行了研究，该仪器能够在全血中研究血小板聚集情况。这可能是一种评估血小板行为的更符合生理的方法，因为避免了离心操作，且血小板是在其他血液成分存在的情况下进行研究的，而这些血液成分在体内可能是血小板功能的重要调节因子。对20名胰岛素依赖型糖尿病患者以及20名年龄和性别匹配的对照组进行了研究。糖尿病组血小板对胶原蛋白（1微克/毫升）和花生四烯酸（1毫摩尔）的聚集显著增加。此外，糖尿病患者血小板对前列环素抗聚集作用的敏感性显著降低。在糖尿病组中，发现血小板对前列环素的敏感性与糖化血红蛋白浓度之间存在显著的负相关。该糖尿病组的血小板异常不太可能是由于潜在的血管疾病所致，因为没有患者有糖尿病并发症的证据。这些发现可能对糖尿病患者血管疾病的发展具有重要意义。
