正常男性口服葡萄糖负荷与静脉注射胰高血糖素作为刺激C肽分泌的比较。

Comparison of oral glucose loading and intravenous glucagon injection as stimuli to C-peptide secretion in normal men.

作者信息

Small M, Cohen H N, Beastall G H, MacCuish A C

出版信息

Diabet Med. 1985 May;2(3):181-3. doi: 10.1111/j.1464-5491.1985.tb00630.x.

DOI:10.1111/j.1464-5491.1985.tb00630.x

Abstract

In 10 healthy men, we have compared the respective effects of an intravenous injection of glucagon (1 mg) and an oral glucose load (75 G) in eliciting the release of C-peptide and insulin from the pancreas. Serum C-peptide and insulin concentrations increased respectively to median values of 190% and 500% at 6 minutes after glucagon injection, and 344% and 794% at 30 minutes and 268% and 278% at 60 minutes following glucose ingestion. The oral glucose load was as effective as glucagon injection in testing beta cell function and was free from the unpleasant side effects (nausea, vomiting, syncope) commonly associated with glucagon. We conclude that oral glucose loading is probably the test of choice to elicit C-peptide release when screening populations of normal subjects for adequacy of beta cell function.

摘要

在10名健康男性中，我们比较了静脉注射胰高血糖素（1毫克）和口服葡萄糖负荷（75克）对胰腺释放C肽和胰岛素的各自影响。注射胰高血糖素后6分钟，血清C肽和胰岛素浓度分别升至中位数的190%和500%，摄入葡萄糖后30分钟分别为344%和794%，60分钟时分别为268%和278%。口服葡萄糖负荷在检测β细胞功能方面与注射胰高血糖素同样有效，且没有通常与胰高血糖素相关的不适副作用（恶心、呕吐、晕厥）。我们得出结论，在筛查正常受试者群体的β细胞功能是否充足时，口服葡萄糖负荷可能是引发C肽释放的首选检测方法。