Wang Tianwei, Gao Ting, Niu Xiaodong, Xing Xiao, Yang Yuan, Liu Yanhui, Mao Qing
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China; Department of Neurosurgery, Xi'an Central Hospital, Xi'an, China.
Department of Pediatrics, Xi'an Children's Hospital, Xi'an, China.
World Neurosurg. 2018 Jun;114:e218-e223. doi: 10.1016/j.wneu.2018.02.168. Epub 2018 Mar 8.
To perform a survival analysis of human immunodeficiency virus (HIV)-patients with glioma and to assess the relationship between various prognostic factors and overall survival (OS).
We reported in detail the management and prognosis of 2 HIV-infected patients with glioma in our hospital and performed a quantitative and comprehensive systematic literature review of patients with HIV-associated glioma. We combined our treatment experience with retrospectively obtained treatment information and studied the survival time to statistically analyze whether age, sex, World Health Organization (WHO) grade, surgery, radiotherapy, chemotherapy, and combined radiotherapy and chemotherapy could predict patient survival.
The study included 34 cases, including our own 2 cases. The median survival was 9 months. On survival analysis, among the aforementioned parameters, WHO grade (low-grade glioma/high-grade glioma), surgery (surgical resection/stereotactic biopsy), and radiotherapy showed a significant association with OS by univariate analysis. Multivariate analysis showed WHO grade and surgery were significant predictors of OS.
Most patients had astrocytoma or high-grade glioma. The median survival of all HIV-infected patients with gliomas was shorter than that of GBM patients with glioblastoma multiforme. Surgery and WHO grade were independent prognostic factors for OS.
对人类免疫缺陷病毒（HIV）感染合并胶质瘤患者进行生存分析，并评估各种预后因素与总生存期（OS）之间的关系。
我们详细报告了我院2例HIV感染合并胶质瘤患者的治疗及预后情况，并对HIV相关胶质瘤患者进行了定量且全面的系统文献综述。我们将自身治疗经验与回顾性获取的治疗信息相结合，研究生存时间，以统计分析年龄、性别、世界卫生组织（WHO）分级、手术、放疗、化疗以及放化疗联合应用是否能够预测患者生存情况。
该研究纳入34例病例，包括我们自己的2例。中位生存期为9个月。生存分析显示，在上述参数中，通过单因素分析，WHO分级（低级别胶质瘤/高级别胶质瘤）、手术（手术切除/立体定向活检）和放疗与总生存期存在显著关联。多因素分析显示，WHO分级和手术是总生存期的显著预测因素。
大多数患者患有星形细胞瘤或高级别胶质瘤。所有HIV感染合并胶质瘤患者的中位生存期短于多形性胶质母细胞瘤患者。手术和WHO分级是总生存期的独立预后因素。
