Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China.
Siberian Federal University, 660041 Krasnoyarsk, Russia.
Mater Sci Eng C Mater Biol Appl. 2018 May 1;86:144-150. doi: 10.1016/j.msec.2017.12.035. Epub 2018 Jan 5.
As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30years. Many studies demonstrated that PHA are promising implant materials due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products.
作为细胞内的碳源和能量储存物质，聚羟基烷酸酯（PHA）是许多细菌合成的一种多样化的生物聚酯。大约 30 年来，PHA 已经被大量生产，用于各种应用研究，包括医学植入物。许多研究表明，PHA 是有前途的植入材料，因为它们具有多样化和上升的机械、生物可降解和组织相容性。重要的是，常见的 PHA 降解产物，包括低聚物和单体，对细胞和组织也没有毒性。一些 PHA 降解产物的药物应用也有报道。到目前为止，还没有研究报告任何 PHA 或其降解产物引起的致癌结果。所有结果表明，PHA 可以开发成各种生物植入产品。
