Kozanoglu Ilknur, Ozdogu Hakan
Baskent University Medical Faculty Department of Physiology, Turkey; Baskent University Dr. Turgut Noyan Research and Training Center Apheresis Unit, Turkey.
Baskent University Dr. Turgut Noyan Research and Training Center Apheresis Unit, Turkey; Baskent University Medical Faculty Department of Hematology, Turkey.
Transfus Apher Sci. 2018 Feb;57(1):23-26. doi: 10.1016/j.transci.2018.02.011. Epub 2018 Feb 21.
Sickle cell disease (SCD) is a life-threatening chronic condition primarily caused by genetic mutation. The disease is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Acute complications in patients with SCD are difficult to manage due to the pathophysiological nature of the disease. Transfusion therapy is the cornerstone of management of acute complications and significantly reduces SCD morbidity and mortality. Red cell exchange (RCE), which is characterized by low iron accumulation and volume overload, has been widely used for transfusion therapy in recent years.
镰状细胞病（SCD）是一种主要由基因突变引起的危及生命的慢性疾病。该疾病的特征是间歇性血管阻塞事件和慢性溶血性贫血。由于该疾病的病理生理特性，SCD患者的急性并发症难以处理。输血治疗是急性并发症管理的基石，可显著降低SCD的发病率和死亡率。红细胞置换（RCE）具有铁蓄积少和容量超负荷的特点，近年来已广泛用于输血治疗。
