Zhang J, Wu H, Ma S, Jing F, Yu C, Gao L, Zhao J
Department of Endocrinology, Shandong Provincial Hospital Affiliated with Shandong University, Jinan, Shandong, P. R. China and Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, P. R. China.
Physiol Res. 2018 Jul 17;67(3):347-362. doi: 10.33549/physiolres.933650. Epub 2018 Mar 12.
The high prevalence of obesity and related metabolic complications has inspired research on adipose tissues. Three kinds of adipose tissues are identified in mammals: brown adipose tissue (BAT), beige or brite adipose tissue and white adipose tissue (WAT). Beige adipocytes share some characteristics with brown adipocytes such as the expression of UCP1. Beige adipocytes can be activated by environmental stimuli or pharmacological treatment, and this change is accompanied by an increase in energy consumption. This process is called white browning, and it facilitates the maintenance of a lean and healthy phenotype. Thus, promoting beige adipocyte development in WAT shows promise as a new strategy in treating obesity and related metabolic consequences. In this review, we summarized the current understanding of the regulators and hormones that participate in the development of brown fat and white fat browning.
肥胖及相关代谢并发症的高发病率激发了对脂肪组织的研究。在哺乳动物中已识别出三种脂肪组织：棕色脂肪组织（BAT）、米色或亮棕色脂肪组织以及白色脂肪组织（WAT）。米色脂肪细胞与棕色脂肪细胞具有一些共同特征，如解偶联蛋白1（UCP1）的表达。米色脂肪细胞可被环境刺激或药物治疗激活，这种变化伴随着能量消耗的增加。这个过程称为白色脂肪棕色化，它有助于维持苗条健康的表型。因此，促进白色脂肪组织中米色脂肪细胞的发育有望成为治疗肥胖及相关代谢后果的新策略。在这篇综述中，我们总结了目前对参与棕色脂肪发育和白色脂肪棕色化的调节因子及激素的认识。
