Esendagli Dorina, Serifoglu Irem, Savas Bozbas Serife, Tepeoglu Merih, Akcay Sule, Haberal Mehmet
Department of Pulmonary Diseases, Baskent University Faculty of Medicine, Ankara, Turkey.
Exp Clin Transplant. 2018 Mar;16 Suppl 1(Suppl 1):176-178. doi: 10.6002/ect.TOND-TDTD2017.P55.
Invasive pulmonary aspergillosis is an infection seen in patients receiving intensive immunosuppressive regimens, such as transplant recipients. Some risk factors that increase the incidence of infection have been determined, and patients defined as having high risk are recommended to take antifungal prophylaxis and be monitored closely. Here, we present a liver transplant patient with mild respiratory symptoms and a normal chest radiography on day 26 posttransplant. However, he had acute renal failure and underwent hemodialysis, which are both defined to increase significantly the risk of aspergillosis. Although the radiographic scan was initially normal, thorax tomography and later bronchoscopy showed findings compatible with pulmonary aspergillosis, and the patient was started on antifungal treatment. The nonspecific mild symptoms and an initial normal radiology can make diagnosis of invasive fungal infections difficult; thus caution and close follow-up of high-risk patients should be performed.
侵袭性肺曲霉病是接受强化免疫抑制方案的患者(如移植受者)中出现的一种感染。已确定了一些增加感染发生率的危险因素,建议被定义为高危的患者进行抗真菌预防并密切监测。在此,我们报告一例肝移植患者,在移植后第26天出现轻微呼吸道症状且胸部X线检查正常。然而,他出现了急性肾衰竭并接受血液透析,这两者均被定义为显著增加曲霉病风险的因素。尽管最初的影像学扫描正常,但胸部断层扫描及随后的支气管镜检查显示了与肺曲霉病相符的表现,该患者开始接受抗真菌治疗。非特异性的轻微症状及最初正常的影像学表现会使侵袭性真菌感染的诊断变得困难;因此,应对高危患者保持警惕并密切随访。