CD81和CD19作为系统性红斑狼疮疾病活动的标志物

CD81 and CD19 as Marker of Activity in Systemic Lupus Erythematosus Disease.

作者信息

Abu-Zahab Zakia, Gad Niveen M, Sabry Seham, Nassib Sherif A

机构信息

Department of Clinical Pathology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.

Department of Medical Microbiology & Immunology, Faculty of Medicine, Benha University, Benha, Egypt.

出版信息

Egypt J Immunol. 2017 Jun;24(2):141-149.

PMID:29528587

Abstract

Systemic Lupus Erythematosus is systematic auto-immune disease characterized by abnormal activation of B cell with production of autoantibodies. Due to its heterogeneous course, there is a need for new markers to help in diagnosing and monitoring disease activity. The aim of this study was to identify the immunopathological role of CD19 and CD81 expression in patients with SLE and their correlation with the disease activity. Peripheral blood (PB) was collected from 40 SLE patients (20 active and 20 inactive) and 20 controls. All were subjected to CBC, Anti-ds DNA, Redial immunodiffusion (RID) for C3 and C4 as activity markers, and detection of CD19 and CD81 surface expression using flow cytometry. CD19 and CD81 were significantly reduced and correlated with disease activity. It is concluded that CD 19 and CD 81 are potential markers for diagnosing and monitoring SLE patients.

摘要

系统性红斑狼疮是一种系统性自身免疫性疾病，其特征为B细胞异常激活并产生自身抗体。由于其病程具有异质性，因此需要新的标志物来辅助诊断和监测疾病活动。本研究的目的是确定CD19和CD81表达在系统性红斑狼疮患者中的免疫病理学作用及其与疾病活动的相关性。收集了40例系统性红斑狼疮患者（20例活动期和20例非活动期）及20例对照者的外周血。所有受试者均接受全血细胞计数、抗双链DNA检测、用于检测C3和C4的单向免疫扩散（RID）作为活动标志物，并使用流式细胞术检测CD19和CD81的表面表达。CD19和CD81显著降低，并与疾病活动相关。得出结论，CD19和CD81是诊断和监测系统性红斑狼疮患者的潜在标志物。