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肠和多器官移植的影像学。

Imaging of Intestinal and Multivisceral Transplantation.

机构信息

From the Departments of Radiology (M.A.R., N.B.A., A.A.B., A.K.D.) and Surgery (R.J.C.), University of Pittsburgh Medical Center, 200 Lothrop St, Radiology Suite 200, East Wing E2051B, Pittsburgh, PA 15213; and Department of Surgery, Cleveland Clinic Foundation, Cleveland, Ohio (K.M.A., G.C.).

出版信息

Radiographics. 2018 Mar-Apr;38(2):413-432. doi: 10.1148/rg.2018170086.

Abstract

Intestinal transplantation has evolved from its experimental origins in the mid-20th century to its status today as an established treatment option for patients with end-stage intestinal failure who cannot be sustained with total parenteral nutrition. The most common source of intestinal failure in both adults and children is short-bowel syndrome, but a host of other disease processes can lead to this common end-point. The development of intestinal transplantation has presented multiple hurdles for the transplant community, including technical challenges, immunologic pitfalls, and infectious complications. Despite these hurdles, the success rate has climbed over the past decades owing to achievements that include improved surgical techniques, new immunosuppressive regimens, and more effective strategies for posttransplant surveillance and management. Nearly 2800 intestinal transplants have been performed worldwide, and current patient and graft survival rates are now comparable to those of other types of solid organ transplantations. As their population continues to increase, it will be increasingly likely that intestinal-transplant patients will seek imaging at sites other than transplant centers. Therefore, it is important that diagnostic and interventional radiologists be familiar with the procedure, its common variations, and the spectrum of postoperative complications. In this article, the authors provide an overview of intestinal transplantation, including the indications, variations, expected postoperative anatomy, and range of potential complications. RSNA, 2018.

摘要

肠移植已经从 20 世纪中叶的实验起源发展到今天,成为不能通过全胃肠外营养维持的终末期肠衰竭患者的一种既定治疗选择。成人和儿童最常见的肠衰竭来源是短肠综合征,但许多其他疾病过程也会导致这种常见的终末结果。肠移植的发展为移植界带来了许多障碍,包括技术挑战、免疫陷阱和感染并发症。尽管存在这些障碍,但由于在过去几十年中取得了成就,包括改进的手术技术、新的免疫抑制方案以及更有效的移植后监测和管理策略,成功率有所提高。全世界已经进行了近 2800 例肠移植,目前患者和移植物的存活率与其他类型的实体器官移植相当。随着其人群的不断增加,肠移植患者在移植中心以外的其他地方进行影像学检查的可能性将越来越大。因此,诊断和介入放射科医生熟悉该手术、其常见变异以及术后并发症谱非常重要。本文作者概述了肠移植,包括适应证、变异、预期的术后解剖结构和潜在并发症范围。RSNA,2018 年。

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