Department of Urology, Luzerner Kantonsspital, Spitalstrasse, Lucerne.
Division of Urology, Department of Surgery, Geneva University Hospital, Switzerland.
Curr Opin Urol. 2018 May;28(3):322-328. doi: 10.1097/MOU.0000000000000500.
GreenLight photoselective vaporization (GL-PV) is now established in the treatment of benign prostatic enlargement. The present review outlines the available technical armamentarium and summarizes the current best evidence on functional and safety outcomes. Moreover, future technical developments and refinements are presented.
GL-PV has evolved to be the most commonly performed procedure, second to conventional transurethral resection of the prostate (TURP) for surgical management of benign prostatic obstruction (BPO). On the basis of the data published in the randomized controlled Goliath study, GL-PV with 180-W technology is noninferior in terms of functional outcomes compared with TURP considering short and intermediate follow-up with a complication-free rate of around 80% after 24 months.The ongoing push towards high-power lasers can be explained by their more effective tissue ablative effect, leading to shorter operating times. Comparative analysis between high-power and low-power laser systems demonstrated similar retreatment rates and most institutions are, therefore, now performing 180-W GL-PV.Performed as an outpatient procedure, GL-PV is cost-effective with a low hospital re-admission rate. Plasma kinetic vaporization of the prostate (PKVP) has recently emerged as a potential contender in the field; also GreenLight enucleation of the prostate (GreenLEP) might be even more effective than GL-PV.
GL-PV appears to be a well tolerated surgical alternative for patients suffering from BPO. Long-term follow-up data from 120-W and 180-W laser systems are still pending. Potential competitors have recently been brought to the market and further trials and long-term data will show, whether GL-PV will stand the test of time. Regardless of technical specifications, surgeon's experience remains essential to achieve good functional and safety outcomes.
绿光前列腺选择性汽化术(GL-PV)目前已被广泛应用于前列腺良性增生的治疗。本文概述了现有的技术手段,并总结了目前在功能和安全性方面的最佳证据。此外,还介绍了未来的技术发展和改进。
GL-PV 已成为仅次于传统经尿道前列腺切除术(TURP)的治疗良性前列腺梗阻(BPO)的最常用手术方法。基于 Goliath 随机对照研究的数据,在短期和中期随访中,180-W 技术的 GL-PV 在功能结果方面不劣于 TURP,其 24 个月后无并发症率约为 80%。目前,高功率激光技术的应用越来越广泛,这是因为其具有更有效的组织消融效果,可缩短手术时间。高功率和低功率激光系统的对比分析表明,两者的再治疗率相似,因此大多数机构现在都在进行 180-W GL-PV 手术。GL-PV 作为一种门诊手术,具有成本效益,且医院再入院率较低。最近,前列腺等离子体剜除术(PKVP)作为一种有潜力的治疗方法出现;而绿光前列腺剜除术(GreenLEP)可能比 GL-PV 更有效。
GL-PV 似乎是 BPO 患者可耐受的一种手术选择。120-W 和 180-W 激光系统的长期随访数据仍在等待中。最近市场上出现了一些潜在的竞争对手,进一步的试验和长期数据将显示 GL-PV 是否经得起时间的考验。无论技术规格如何,外科医生的经验仍然是实现良好功能和安全性结果的关键。