Bristol Urological Institute, Bristol, UK.
Curr Opin Urol. 2018 May;28(3):267-272. doi: 10.1097/MOU.0000000000000496.
Benign prostatic obstruction (BPO) is a common cause of lower urinary tract symptoms (LUTS) in elderly men. However, such symptoms are often caused by primary detrusor overactivity or underactivity. Surgical management where BPO is absent or merely incidental has a lower chance of success, and exposes the patient to the potential complications of surgery. This review discusses the diagnostic challenges facing this common presentation.
Most evidence comes from small, historical prospective cohort studies. A Cochrane review found only two studies that met the prespecified inclusion criteria. It concluded that urodynamics changed decision-making regarding surgery for LUTS but it was not possible to determine whether this impacted upon outcome. A systematic review of several noninvasive alternatives to urodynamics could not recommend any of them over urodynamic pressure-flow study assessment. Further research is currently in progress, the 'UPSTREAM' study, which is a randomized, multicentre trial. Men are randomized to undergo investigation with clinical evaluation and uroflowmetry, or to additionally receive urodynamics. The primary aim is to determine the impact of urodynamics on the assessment pathway.
Assessment of BPO involves determining whether it has a contributory role in individual patients. This is a crucial factor in outcome, as surgery can give poor results if the symptoms are principally caused by detrusor dysfunction (overactivity or underactivity). Urodynamics can help determine this if undertaken to a suitable standard. Further research will identify the precise role of this test modality.
良性前列腺增生(BPO)是老年男性下尿路症状(LUTS)的常见原因。然而,这些症状通常是由原发性逼尿肌过度活动或活动不足引起的。如果不存在 BPO 或仅为偶然发现,则手术治疗的成功率较低,并且会使患者面临手术的潜在并发症。本文综述讨论了这种常见表现所面临的诊断挑战。
大多数证据来自于小型的、历史前瞻性队列研究。一项 Cochrane 综述仅发现了两项符合预设纳入标准的研究。该综述得出结论,尿动力学改变了 LUTS 手术决策,但无法确定这是否会影响手术结果。对几种非侵入性替代尿动力学检查的系统评价无法推荐其中任何一种替代尿动力学压力-流研究评估。目前正在进行进一步的研究,即“UPSTREAM”研究,这是一项随机、多中心试验。男性随机分为接受临床评估和尿流率检查或另外接受尿动力学检查。主要目的是确定尿动力学检查对评估途径的影响。
BPO 的评估涉及确定其在个体患者中是否具有促成作用。这是结局的一个关键因素,因为如果症状主要由逼尿肌功能障碍(过度活动或活动不足)引起,则手术可能会产生较差的结果。如果按照适当的标准进行尿动力学检查,可以帮助确定这一点。进一步的研究将确定该测试方式的确切作用。