AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden.
The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, EH25 9RG UK.
Genetics. 2018 May;209(1):209-221. doi: 10.1534/genetics.118.300810. Epub 2018 Mar 12.
The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated five strong candidate genes, with the gene being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.
鉴定影响社会性的基因可以深入了解社会性和个性的维持和发展。在这项研究中，我们使用野生和家养鸡的高级杂交组合，结合 QTL 和 eQTL 遗传基因组学方法，鉴定了与社会恢复相关的社交和焦虑行为的基因。总共鉴定了 24 个社会恢复 QTL，并与使用下丘脑组织从同一批鸟类中获得的 600 多个 eQTL 重叠。重叠 QTL 和 eQTL 之间的相关性表明了五个强有力的候选基因，其中基因与社会恢复行为的多个方面强烈相关，并且具有高度显著的 eQTL。
