[Glycosaminoglycans and glycan hydrolases in the kidney of rats with hereditary diabetes insipidus].

Distribution of glycanohydrolases activity (hyaluronidase, beta-glucuronidase, N-acetyl-beta-D-hexosaminidase) and glycosaminoglycans in different renal zones (papilla, external medulla, cortex) of homo- and heterozygous Brattleboro rats with hereditary defect of antidiuretic hormone synthesis was studied. Content of the glycosaminoglycans in kidney preparations of homozygotes was shown to be minimal as compared with other rodents; at the same time, the activity of glycanohydrolases in the papilla of diabetic rats was comparatively high. Administration of the antidiuretic hormone at physiological doses was followed by the same increase in the enzymatic activity in renal papilla of homo- and heterozygotes, while certain correlation between the urine osmolality and the degree of the enzymes activation was observed.