Palkoci B, Vojtko M, Fialová J, Osinová D, Lajčiaková M
Surgery Clinic and Transplant Center, University Hospital Martin and Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Department of Anaesthesiology and Intensive Medicine, University Hospital, Martin and Jessenius Faculty of Medicine, Comenius University, Slovakia.
Int J Organ Transplant Med. 2018;9(1):1-9. Epub 2018 Feb 1.
Collection of kidneys from extended criteria donors (ECD) with diagnosed brain-death forms a part of the collection program that increases the number of transplantations.
To compare the results of ECD with those of standard criteria donors (SCD).
In a retrospective analysis in a group of 156 kidney donors, we identified ECD donors. We detected the basic parameters of the donors before kidney collection, and then evaluated the function of the graft, the survival of the graft, and the survival of the patients after 1, 3, and 5 years of transplantation. The results were then compared with the function of the graft from those of SCD donors.
The ECD donors were significantly (p<0.001) older than the SCD donors. They had a higher body mass index (p=0.006) and prevalence of hypertension (p<0.001) and diabetes mellitus (p=0.004) compared to SCD donors. The graft function within the first 6 months and the survival of recipients in the first year of transplantation were significantly worse in ECD than in SCD groups (p=0.01, and 0.023, respectively). No difference in the graft survival was observed between the two groups.
The long-term function of the graft and survival of patients and grafts in recipients of kidneys from ECD donors are comparable to SCD donors. Exploitation of the given organs for transplantation is important due to the constantly increasing demand versus limited offer of organs.
从已诊断为脑死亡的扩大标准供体（ECD）中采集肾脏是增加移植数量的采集计划的一部分。
比较ECD与标准标准供体（SCD）的结果。
在一组156名肾脏供体的回顾性分析中，我们确定了ECD供体。我们在采集肾脏前检测了供体的基本参数，然后评估了移植后1年、3年和5年时移植物的功能、移植物的存活情况以及患者的存活情况。然后将结果与SCD供体的移植物功能进行比较。
ECD供体的年龄显著高于SCD供体（p<0.001）。与SCD供体相比，他们的体重指数更高（p=0.006），高血压患病率（p<0.001）和糖尿病患病率（p=0.004）更高。ECD组移植后前6个月内的移植物功能和移植后第一年受者的存活率显著低于SCD组（分别为p=0.01和0.023）。两组之间未观察到移植物存活的差异。
ECD供体肾脏受者的移植物长期功能以及患者和移植物的存活率与SCD供体相当。由于器官需求不断增加而供应有限，利用给定器官进行移植很重要。
