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GCN2 controls the cellular checkpoint: potential target for regulating inflammation.

作者信息

Xia Xiaojing, Lei Liancheng, Qin Wanhai, Wang Lei, Zhang Gaiping, Hu Jianhe

机构信息

1College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.

2Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang, China.

出版信息

Cell Death Discov. 2018 Feb 14;4:20. doi: 10.1038/s41420-017-0022-5. eCollection 2018 Dec.

DOI:10.1038/s41420-017-0022-5
PMID:29531817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5841328/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db70/5841328/35fc29e93f73/41420_2017_22_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db70/5841328/35fc29e93f73/41420_2017_22_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db70/5841328/35fc29e93f73/41420_2017_22_Fig1_HTML.jpg

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The cellular autophagy/apoptosis checkpoint during inflammation.炎症过程中的细胞自噬/凋亡检查点。
Cell Mol Life Sci. 2017 Apr;74(7):1281-1296. doi: 10.1007/s00018-016-2403-y. Epub 2016 Nov 11.
3
Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells.
Acta Pharmacol Sin. 2024 Jun;45(6):1095-1114. doi: 10.1038/s41401-023-01225-0. Epub 2024 Jan 24.
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General Control Non-derepressible 2 Alleviates Cartilage Degeneration and Inhibits NLRP3 Inflammasome Activation in Osteoarthritis.普遍调控不可抑制因子 2 减轻骨关节炎软骨退化并抑制 NLRP3 炎性小体激活。
J Histochem Cytochem. 2024 Feb;72(2):95-108. doi: 10.1369/00221554231225514. Epub 2024 Jan 11.
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Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro.链球菌精氨酸脱亚氨酶在体外抑制T淋巴细胞分化。
Microorganisms. 2023 Oct 19;11(10):2585. doi: 10.3390/microorganisms11102585.
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Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice.在GCN2基因敲除小鼠中多胺阻断疗法抗肿瘤功效的丧失。
Biomedicines. 2023 Oct 5;11(10):2703. doi: 10.3390/biomedicines11102703.
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