Suppr超能文献

链球菌性人工关节感染患者的治疗结果——一项回顾性基于人群的研究。

Successful outcome for patients with streptococcal prosthetic joint infections - a retrospective population-based study.

机构信息

a Division of Infectious Diseases , Skåne University Hospital , Lund , Sweden.

b Department of Clinical Sciences, Division of Infection Medicine , Lund University, Skåne University Hospital , Lund , Sweden.

出版信息

Infect Dis (Lond). 2018 Aug;50(8):593-600. doi: 10.1080/23744235.2018.1449961. Epub 2018 Mar 13.

Abstract

BACKGROUND/AIM: Streptococci cause approximately 10% of prosthetic joint infections (PJIs). The aim of this study was to identify the characteristics of patients with streptococcal PJIs and to describe the treatment and outcome of streptococcal PJIs in Skåne county between 2011 and 2015.

METHODS

Patients with streptococcal PJIs with positive cultures or PCRs on samples from joint aspirate and/or periprosthetic tissue between 2011 and 2015 in Skåne county, were identified and medical records were studied.

RESULTS

Eighty-three PJI episodes treated at seven hospitals were identified. The median age was 70 years (IQR: 64-78) and there were more men (61%) than women. Hip joints were the most common site of isolation (54%). The most frequently isolated pathogens were beta-haemolytic streptococci of groups A, C and G (31%), group B (30%), and alpha-haemolytic streptococci (23%). Overall failure rate was 11% (n = 9), and lack of comorbidity was significantly associated with a favourable outcome. The most common treatment strategy was debridement, antibiotic treatment and implant retention (DAIR) (n = 64; 77%) and the initial success rate using this strategy was 84% (n = 53).

CONCLUSION

This study indicates an acceptable success rate for the patients treated with DAIR strategy, and a high overall success rate for episodes suffering streptococcal PJIs.

摘要

背景/目的:链球菌约占人工关节感染(PJI)的 10%。本研究旨在确定链球菌 PJI 患者的特征,并描述 2011 年至 2015 年在斯科讷县链球菌 PJI 的治疗和结果。

方法

在斯科讷县,2011 年至 2015 年间,对关节抽吸和/或假体周围组织中培养或 PCR 阳性的链球菌 PJI 患者进行鉴定,并对病历进行研究。

结果

在 7 家医院治疗的 83 例 PJI 发作中,中位年龄为 70 岁(IQR:64-78),男性(61%)多于女性。髋关节是最常见的分离部位(54%)。最常分离的病原体是 A、C 和 G 组β溶血性链球菌(31%)、B 组(30%)和α溶血性链球菌(23%)。总失败率为 11%(n=9),无合并症与良好结局显著相关。最常见的治疗策略是清创术、抗生素治疗和保留植入物(DAIR)(n=64;77%),该策略的初始成功率为 84%(n=53)。

结论

本研究表明,采用 DAIR 策略治疗的患者成功率可接受,且链球菌 PJI 发作的总体成功率较高。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验