1 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
2 Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania-"Luigi Vanvitelli," Naples, Italy.
J Dent Res. 2018 Jul;97(7):759-766. doi: 10.1177/0022034518762090. Epub 2018 Mar 13.
Oral squamous cell carcinoma (OSCC) is a common type of cancer characterized by a low survival rate, mostly due to local recurrence and metastasis. In view of the importance of predicting tumor behavior in the choice of treatment strategies for OSCC, several studies have attempted to investigate the prognostic value of tissue biomarkers, including microRNA (miRNA). The purpose of this study was to perform a systematic review and meta-analysis to evaluate the relationship between miRNA expression and survival of OSCC patients. Studies were identified by searching on MEDLINE/PubMed, SCOPUS, Web of Science, and Google Scholar. Quality assessment of studies was performed with the Newcastle-Ottawa Scale. Data were collected from cohort studies comparing disease-free survival and overall survival in patients with high miRNA expression compared to those with low expression. A total of 15 studies featuring 1,200 OSCC samples, predominantly from Asia, met the inclusion criteria and were included in the meta-analysis. Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b). The pooled hazard ratio values (95% confidence interval) related to different miRNA expression for overall survival and disease-free survival were 2.65 (2.07-3.39) and 1.95 (1.28-2.98), respectively. The results of this meta-analysis revealed that the expression levels of specific miRNAs can robustly predict prognosis of OSCC patients.
口腔鳞状细胞癌 (OSCC) 是一种常见的癌症类型，其生存率较低，主要原因是局部复发和转移。鉴于预测肿瘤行为对于 OSCC 治疗策略选择的重要性，已有多项研究试图探讨组织生物标志物（包括 microRNA (miRNA)）的预后价值。本研究旨在进行系统评价和荟萃分析，以评估 miRNA 表达与 OSCC 患者生存之间的关系。通过在 MEDLINE/PubMed、SCOPUS、Web of Science 和 Google Scholar 上进行搜索，确定了研究。使用纽卡斯尔-渥太华量表对研究进行质量评估。从比较高 miRNA 表达组与低 miRNA 表达组患者疾病无进展生存率和总生存率的队列研究中收集数据。共有 15 项研究符合纳入标准，共纳入 1200 例 OSCC 样本，主要来自亚洲，并纳入荟萃分析。上调 9 种 miRNA（miR-21、miR-455-5p、miR-155-5p、miR-372、miR-373、miR-29b、miR-1246、miR-196a 和 miR-181）和下调 7 种 miRNA（miR-204、miR-101、miR-32、miR-20a、miR-16、miR-17 和 miR-125b）与不良预后相关。不同 miRNA 表达与总生存率和无病生存率相关的汇总风险比值（95%置信区间）分别为 2.65（2.07-3.39）和 1.95（1.28-2.98）。荟萃分析结果表明，特定 miRNA 的表达水平可以可靠地预测 OSCC 患者的预后。
