van Dam Paul Mel, van Geffen Mark Wl, Havenith Thomas Ra, Posthouwer Dirk
Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
Department of Clinical Pharmacy, Maastricht University Medical Center, Maastricht, the Netherlands.
Antivir Ther. 2018;23(6):549-552. doi: 10.3851/IMP3229.
Triumeq is a single-tablet regimen for patients with HIV infection comprising dolutegravir, abacavir and lamivudine. Overdoses with Triumeq have not been reported previously. We present a case of a 26-year-old man who presented to our hospital after intentionally ingesting 30 tablets of Triumeq. An intoxication with Triumeq can lead to several side effects. An overdose of abacavir and lamivudine can cause mitochondrial toxicity and lactic acidosis. An intoxication with dolutegravir appears to be relatively harmless. As Triumeq will be used on a regular basis as treatment for patients with HIV-1 infection, these intoxications are expected to be encountered more often.
绥美凯是一种用于治疗HIV感染患者的单片复方制剂，其成分包括多替拉韦、阿巴卡韦和拉米夫定。此前尚未有过绥美凯过量服用的报道。我们报告了一例26岁男性患者，他在故意服用30片绥美凯后前来我院就诊。绥美凯中毒可导致多种副作用。阿巴卡韦和拉米夫定过量可引起线粒体毒性和乳酸性酸中毒。多替拉韦中毒似乎相对无害。由于绥美凯将作为HIV-1感染患者的常规治疗药物使用，预计这类中毒情况会更频繁地出现。
