评价含有醋酸曲洛酮和 17β-雌二醇的包被甾体植入物对育肥公牛的活体性能、胴体特征和血清代谢物的影响。
Evaluation of coated steroidal implants containing trenbolone acetate and estradiol-17β on live performance, carcass traits, and sera metabolites in finishing steers.
机构信息
Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX.
Merck Animal Health, Madison, NJ.
出版信息
J Anim Sci. 2018 May 4;96(5):1704-1723. doi: 10.1093/jas/sky095.
Crossbred beef steers (n = 240; 12 pens/treatment; initial BW = 305 ± 17.7 kg) were used in a randomized block design feedlot study to evaluate the influence of coated trenbolone acetate (TBA) and estradiol-17β (E2) implants (Merck Animal Health, Madison, NJ) on gain performance, carcass traits, and sera metabolites. The five treatments were no implant (NI), Revalor-XR on d 0 [200 mg TBA + 20 mg E2 (coated); XR], Revalor-XS on d 0 [200 mg TBA + 40 mg E2 (total): 80 mg TBA + 16 mg E2 (noncoated) and 120 mg TBA + 24 mg E2 (coated); XS], Revalor-200 on d 0 [200 mg TBA + 20 mg E2 (noncoated); E200], or Revalor-200 on d 70 (D200). Interim BW and blood were collected on d 0, 14, 35, 70, 105, 140, and 175 prior to feeding and on d 213 prior to shipping. Following a 24 h clot at 4 °C, sera was harvested to quantify circulating E2, IGF-I, NEFA, serum urea-N (SUN), and 17β-trenbolone (17β-TbOH). Implanted steers had greater (P ≤ 0.05) ADG, G:F, and final BW than NI controls. Implants increased (P < 0.05) HCW by 8%, 366 vs. 391, 414, 380, and 396 ± 6.4 kg, for NI vs. XR, XS, E200, and D200, respectively. The greatest (P ≤ 0.05) dressing percentage, yield grade, and calculated empty body fat occurred in XS, which had greater (P < 0.05) rib fat than NI, XR, and D200. Marbling scores in NI were greater (P < 0.05) than E200 and D200; steers in XR and XS were intermediate (P > 0.10), not differing from NI, E200, or D200. An implant × day interaction (P ≤ 0.01) was noted for circulating E2, IGF-I, SUN, and 17β-TbOH. Implanted steers had elevated (P ≤ 0.05) sera E2, IGF-I, and 17β-TbOH, and decreased (P < 0.05) SUN following implantation compared to NI controls. Serum NEFA differed (P < 0.01) over time, but did not differ (P > 0.10) due to implant treatment. These data indicated that the polymer coating applied to the XR implant delayed release of steroidal hormones congruently to D200, with no negative impact on marbling. The greatest dose of E2, contained in XS, provided improvements in gain and carcass weight without detriment to marbling scores compared to NI.
杂交肉牛（n = 240；12 个处理栏；初始 BW = 305 ± 17.7 kg）被用于一项随机分组设计的肥育研究中，以评估包被型 trenbolone 乙酸酯（TBA）和雌二醇-17β（E2）植入物（默克动物健康，麦迪逊，新泽西州）对增重性能、胴体性状和血清代谢物的影响。五种处理方法为无植入物（NI）、Revalor-XR 处理组 d0 [200 mg TBA + 20 mg E2（包被）；XR]、Revalor-XS 处理组 d0 [200 mg TBA + 40 mg E2（总剂量）：80 mg TBA + 16 mg E2（非包被）和 120 mg TBA + 24 mg E2（包被）；XS]、Revalor-200 处理组 d0 [200 mg TBA + 20 mg E2（非包被）；E200]或 Revalor-200 处理组 d70（D200）。在喂食前，每隔一天在 d0、14、35、70、105、140 和 175 以及在 d213 进行体重和血液采集。在 4°C 下静置 24 小时后，采集血清以定量循环中的 E2、IGF-I、NEFA、血清尿素氮（SUN）和 17β- trenbolone（17β-TbOH）。植入组的 ADG、G:F 和最终 BW 均高于 NI 对照组（P ≤ 0.05）。植入物使 HCW 增加（P < 0.05），分别为 8%、366 比 391、414、380 和 396 ± 6.4 kg，NI 比 XR、XS、E200 和 D200。XS 的 dressing percentage、yield grade 和计算的空体脂肪最高（P ≤ 0.05），XS 的肋骨脂肪比 NI、XR 和 D200 高（P < 0.05）。NI 的大理石纹评分高于 E200 和 D200（P < 0.05）；XR 和 XS 中的牛处于中间（P > 0.10），与 NI、E200 或 D200 无差异。循环中的 E2、IGF-I、SUN 和 17β-TbOH 出现了植入物×天的交互作用（P ≤ 0.01）。与 NI 对照组相比，植入组的血清 E2、IGF-I 和 17β-TbOH 升高（P ≤ 0.05），SUN 降低（P < 0.05）。血清 NEFA 随时间变化而不同（P < 0.01），但由于植入物处理而没有差异（P > 0.10）。这些数据表明，XR 植入物上应用的聚合物涂层延迟了 steroidal hormones 的释放，与 D200 一致，对大理石纹没有负面影响。XS 中包含的最大剂量的 E2 与 NI 相比，提高了增重和胴体重，而不会降低大理石纹评分。
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