复杂颈静脉鼓室副神经节瘤患者的疾病及治疗相关后遗症

Disease and Treatment-Related Sequelae in Patients with Complex Jugulotympanic Paraganglioma.

作者信息

Harati Ali, Schultheiß Rolf, Rohde Stefan, Deitmer Thomas

机构信息

Neurosurgical Department, Klinikum Dortmund, 44145 Dortmund, Germany.

Department of Radiology and Neuroradiology, Klinikum Dortmund, 44145 Dortmund, Germany.

出版信息

J Clin Med. 2018 Mar 10;7(3):51. doi: 10.3390/jcm7030051.

DOI:10.3390/jcm7030051

PMID:29534458

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5867577/

Abstract

BACKGROUND

Jugulotympanic paraganglioma (JTP) are benign, high-vascularized lesions that frequently invade the jugular foramen, temporal bone, the upper neck, and the posterior fossa cavity, resulting in a wide variety of clinical symptoms.

METHODS

In this retrospective study, we assess the clinical symptoms and discuss the individual multidisciplinary treatment and outcome of 22 patients with JTP.

RESULTS

In 12 patients, a hearing deficit was the presenting symptom, whereas pulsatile tinnitus and otalgia were present in six and four patients respectively. Facial nerve involvement was seen in six patients (three HB Grade 1-2 and three HB Grade 4-6). Four patients presented with lower cranial nerve impairment. Rare symptoms were ataxia caused by brainstem compression and papilledema due to cerebral sinus obstruction. A new or worsening of the preoperative facial nerve or lower cranial nerve function occurred in two and four patients respectively.

CONCLUSION

The treatment strategy and the surgical approach for JTP should be tailored to the tumor extension and the patient's clinical symptoms.

摘要

背景

颈静脉鼓室副神经节瘤（JTP）是良性、高血管化病变，常侵犯颈静脉孔、颞骨、上颈部和后颅窝腔，导致多种临床症状。

方法

在这项回顾性研究中，我们评估了22例JTP患者的临床症状，并讨论了个体化多学科治疗及结果。

结果

12例患者以听力减退为首发症状，6例和4例患者分别出现搏动性耳鸣和耳痛。6例患者出现面神经受累（3例House-Brackmann分级1-2级，3例House-Brackmann分级4-6级）。4例患者出现下颅神经损伤。罕见症状包括脑干受压引起的共济失调和脑窦阻塞导致的视乳头水肿。分别有2例和4例患者术前面神经或下颅神经功能出现新的损害或恶化。