高效的化学酶法合成 Rugulactone 的方法。
An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone.
机构信息
Department of Chemistry, University of Crete, Vasilika Vouton, 71003 Heraklion, Crete, Greece.
出版信息
Molecules. 2018 Mar 12;23(3):640. doi: 10.3390/molecules23030640.
Abstract
Rugulactone is a natural product isolated from the plant . It has shown very important biological activity as an inhibitor of the nuclear factor κB (NF-κB) activation pathway. A new chemoenzymatic approach towards the synthesis of rugulactone is presented here. The chirality, induced to the key intermediate by a stereoselective enzymatic reduction utilizing NADPH-dependent ketoreductase, is described in detail.
摘要
瑞格芦亭是一种从植物中分离得到的天然产物。它作为核因子-κB（NF-κB）激活途径抑制剂显示出非常重要的生物学活性。本文介绍了一种新的化学酶法合成瑞格芦亭的方法。详细描述了利用 NADPH 依赖的酮还原酶进行立体选择性酶促还原，在关键中间体中诱导的手性。
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