Neoplasma. 2018;65(2):292-295. doi: 10.4149/neo_2018_170318N194.
Cytoplasmic FMR1 interacting protein 1 (Cyfip1) is a new candidate tumor suppressor gene, which may play an impor- tant role in the occurrence and development of cancers. However, the role of Cyfip1 in nasopharyngeal carcinoma (NPC) remains poorly known. The aim of this study was to investigate the Cyfip1 mRNA expression in NPC and its association with clinicopathological features. The study population comprised 114 Chinese individuals, including 69 NPC tissues and 45 non-cancerous nasopharyngeal tissues. We used real-time fluorescent relatively quantitative PCR to evaluate the Cyfip1 mRNA expression in NPC tissues and non-cancerous nasopharyngeal tissues. The expression level of Cyfip1 mRNA was significantly lower in patients with NPC than in the control samples (p=0.001). Furthermore, low expression level of Cyfip1 mRNA was significantly associated with invasive range (T3-T4 vs T1-T2, p=0.001), lymph node metastasis (N1-N3 vs N0, p=0.010), distant metastases (M1 vs M0, p=0.040) and clinical stage (III-IV vs I-II, p<0.001). Our results suggest the association between Cyfip1 mRNA expression and NPC. Detecting the expression of Cyfip1 may provide clinically useful information for diagnosis, progression and treatment methods in NPC.
细胞质脆性 X 智力低下蛋白 1 相互作用蛋白 1（Cyfip1）是一种新的候选肿瘤抑制基因，可能在癌症的发生和发展中发挥重要作用。然而，Cyfip1 在鼻咽癌（NPC）中的作用知之甚少。本研究旨在探讨 Cyfip1 在 NPC 中的 mRNA 表达及其与临床病理特征的关系。研究人群包括 114 名中国人，包括 69 例 NPC 组织和 45 例非癌性鼻咽组织。我们使用实时荧光相对定量 PCR 评估 NPC 组织和非癌性鼻咽组织中的 Cyfip1 mRNA 表达。与对照组相比，NPC 患者的 Cyfip1 mRNA 表达水平明显降低（p=0.001）。此外，Cyfip1 mRNA 低表达与浸润范围（T3-T4 与 T1-T2，p=0.001）、淋巴结转移（N1-N3 与 N0，p=0.010）、远处转移（M1 与 M0，p=0.040）和临床分期（III-IV 与 I-II，p<0.001）显著相关。我们的结果表明 Cyfip1 mRNA 表达与 NPC 之间存在关联。检测 Cyfip1 的表达可能为 NPC 的诊断、进展和治疗方法提供临床有用的信息。
