Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon; Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon.
Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Sleep Med Rev. 2018 Oct;41:133-140. doi: 10.1016/j.smrv.2018.02.002. Epub 2018 Feb 13.
Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions.
昼夜节律紊乱在双相情感障碍（BD）中很常见。睡眠-觉醒时相延迟综合征（DSWPD）是最常见的昼夜节律睡眠-觉醒障碍（CRSWD），在 BD 中经常观察到。目前尚不清楚 BD 中的 DSWPD 是一个独立的过程还是 BD 的结果。在本假设性综述中，我们讨论了 BD 和 DSWPD 之间的重叠以及 DSWPD 和 BD 的潜在共同生物标志物。综述将包括对 DSWPD 和 BD 遗传学的讨论。阐明这两种疾病中发生的病理生理过程的生物标志物可能为这两种疾病的病因和预后提供见解。
