Laustsen Andreas H, María Gutiérrez José, Knudsen Cecilie, Johansen Kristoffer H, Bermúdez-Méndez Erick, Cerni Felipe A, Jürgensen Jonas A, Ledsgaard Line, Martos-Esteban Andrea, Øhlenschlæger Mia, Pus Urska, Andersen Mikael R, Lomonte Bruno, Engmark Mikael, Pucca Manuela B
Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
Toxicon. 2018 May;146:151-175. doi: 10.1016/j.toxicon.2018.03.004. Epub 2018 Mar 10.
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being investigated for the ability to neutralize animal toxins. These different molecular formats each have their own therapeutic characteristics. In this review, we provide an overview of the advances made in the development of toxin-targeting antibodies, and discuss the benefits and drawbacks of different antibody formats in relation to their ability to neutralize toxins, pharmacokinetic features, propensity to cause adverse reactions, formulation, and expression for research and development (R&D) purposes and large-scale manufacturing. A research trend seems to be emerging towards the use of human antibody formats as well as camelid heavy-domain antibody fragments due to their compatibility with the human immune system, beneficial therapeutic properties, and the ability to manufacture these molecules cost-effectively.
抗体技术在毒素学领域的应用日益广泛。在免疫学、合成生物学和抗体研究取得诸多进展的推动下，人们正在研究不同方法和抗体形式用于中和动物毒素的能力。这些不同的分子形式各自具有独特的治疗特性。在本综述中，我们概述了毒素靶向抗体开发方面取得的进展，并讨论了不同抗体形式在中和毒素能力、药代动力学特征、引发不良反应的倾向、制剂以及用于研发和大规模生产的表达方面的优缺点。由于与人免疫系统的兼容性、有益的治疗特性以及经济高效地生产这些分子的能力，使用人抗体形式以及骆驼科动物重链结构域抗体片段似乎正成为一种研究趋势。
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