Imashuku Shinsaku, Kobayashi Miyako, Nishii Yoichi, Nishimura Keisuke
Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, Japan.
Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, Japan.
Case Rep Dermatol Med. 2018 Jan 3;2018:1680871. doi: 10.1155/2018/1680871. eCollection 2018.
Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed. Thereafter, we found topical imiquimod to be effective in the treatment of relapsed cutaneous LCH lesions.
