Razdan Anupriya, Viswanathan Ramaswamy, Tusher Alan
SUNY Downstate Medical Center, Brooklyn, NY, USA.
Case Rep Psychiatry. 2018 Feb 4;2018:1232535. doi: 10.1155/2018/1232535. eCollection 2018.
Proton pump inhibitors (PPIs) are frequently prescribed antiulcer agents in hospitals and are shown to be safer than H-2 blockers. We present a case report of PPI-induced delirium, regarding which not much has been written in the literature.
We present a case of a 93-year-old woman with no known past psychiatric history, who was hospitalized for syncope workup and who developed delirium after a double dose of pantoprazole.
Very few reports of PPI-induced delirium exist in the literature. In this case report, we attempt to highlight the mechanism of PPI induced delirium which in our case was most likely due to the primary effects of PPI and drug-drug interactions. Given the paucity of literature on this topic, we encourage further research into relationship between PPI and delirium and urge caution while using PPIs in geriatric population.
质子泵抑制剂（PPIs）是医院中常用的抗溃疡药物，且已证明比H-2阻滞剂更安全。我们报告一例PPI诱发谵妄的病例，关于此在文献中记载不多。
我们呈现一例93岁女性，既往无精神病史，因晕厥检查入院，在双倍剂量泮托拉唑治疗后出现谵妄。
文献中关于PPI诱发谵妄的报道极少。在本病例报告中，我们试图强调PPI诱发谵妄的机制，在我们的病例中最可能是由于PPI的主要作用及药物相互作用。鉴于关于该主题的文献匮乏，我们鼓励进一步研究PPI与谵妄之间的关系，并敦促在老年人群中使用PPIs时要谨慎。
