印度东部大吉岭地区雷布查人的一项遗传学研究。

A genetic study among the Lepchas of the Darjeeling area of eastern India.

作者信息

Saha N, Bhattacharyya S P, Mukhopadhyay B, Bhattacharyya S K, Gupta R, Basu A

出版信息

Hum Hered. 1987;37(2):113-21. doi: 10.1159/000153686.

Abstract

A total of 215 Lepchas (75 Buddhists and 140 Christians) living in the Kalimpong subdivision, Darjeeling district, West Bengal, India, were investigated for the distribution of haemoglobin, serum proteins and red cell enzymes. The gene frequencies were as follows: HbE = 0.02; Hp1 = 0.18; TfB = 0.007; TfDChi = 0.005; Gc2 = 0.22; pa = 0.18; pc = 0.03; PGM2(1) = 0.18; PGM6(1) = 0.002; PGDc = 0.17; AK2 = 0.02; GLO1 = 0.21. The most striking features were the complete lack of G6PD deficiency and very high frequency of PGDC. The remaining loci (serum albumin, lactate dehydrogenase, malate dehydrogenase and glucose-6-phosphate dehydrogenase, phosphohexose isomerase and superoxide dismutase) were monomorphic. The gene frequencies were similar in the Buddhist and Christian Lepchas. The observed average heterozygosity (9 loci) was 0.20 in the entire sample.

摘要

对居住在印度西孟加拉邦大吉岭地区卡林蓬分区的215名雷布查人（75名佛教徒和140名基督教徒）进行了血红蛋白、血清蛋白和红细胞酶分布的调查。基因频率如下：HbE = 0.02；Hp1 = 0.18；TfB = 0.007；TfDChi = 0.005；Gc2 = 0.22；pa = 0.18；pc = 0.03；PGM2(1) = 0.18；PGM6(1) = 0.002；PGDc = 0.17；AK2 = 0.02；GLO1 = 0.21。最显著的特征是完全缺乏葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症，且PGDC的频率非常高。其余位点（血清白蛋白、乳酸脱氢酶、苹果酸脱氢酶、葡萄糖-6-磷酸脱氢酶、磷酸己糖异构酶和超氧化物歧化酶）均为单态性。佛教和基督教雷布查人的基因频率相似。在整个样本中，观察到的平均杂合度（9个位点）为0.20。