急性冠状动脉综合征的微小RNA检测

microRNA assays for acute coronary syndromes.

作者信息

Shirvani Samani Omid, Meder Benjamin

机构信息

1Institute for Cardiomyopathies Heidelberg, Department of Cardiology, Angiology and Pulmology, University of Heidelberg, Heidelberg, Germany.

出版信息

Diagnosis (Berl). 2016 Dec 1;3(4):183-188. doi: 10.1515/dx-2016-0025.

DOI:10.1515/dx-2016-0025

PMID:29536899

Abstract

microRNAs are promising biomarkers for diverse cardiovascular diseases. While quantification of the small non-coding RNAs is routinely performed in the research laboratory, clinical-grade assessment of microRNAs in central laboratory environments or point-of-care testing is still in its infancy. In this review, we provide an overview on microRNAs as biomarkers for acute coronary syndromes and highlight promising technical approaches for microRNA-based assays systems.

摘要

微小RNA是多种心血管疾病颇具前景的生物标志物。虽然在研究实验室中常规地对这些小的非编码RNA进行定量分析，但在中心实验室环境或即时检测中对微小RNA进行临床级评估仍处于起步阶段。在本综述中，我们概述了微小RNA作为急性冠状动脉综合征生物标志物的情况，并重点介绍了基于微小RNA的检测系统的有前景的技术方法。