循环肿瘤细胞：诊断与治疗应用。

Circulating Tumor Cells: Diagnostic and Therapeutic Applications.

机构信息

Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA; email:

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA.

出版信息

Annu Rev Biomed Eng. 2018 Jun 4;20:329-352. doi: 10.1146/annurev-bioeng-062117-120947. Epub 2018 Mar 14.

DOI:10.1146/annurev-bioeng-062117-120947

PMID:29539267

Abstract

Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. We discuss the advantages and limitations of such strategies and how they may lead to the development of the next generation of antimetastasis treatments.

摘要

转移是许多类型癌症预后不良的主要原因，也是癌症相关死亡的主要原因。肿瘤细胞通过循环系统和淋巴系统转移到远处部位。在这篇综述中，我们讨论了循环肿瘤细胞在诊断中的潜力，并描述了旨在靶向这些播散癌细胞的实验治疗方法。我们讨论了这些策略的优缺点，以及它们如何可能导致下一代抗转移治疗方法的发展。