来自16世纪意大利撒丁岛的一例疑似非综合征性短头畸形病例。

A probable case of non-syndromic brachycephaly from 16th century Sardinia (Italy).

作者信息

Giuffra V, Bianucci R, Milanese M, Fornaciari G

机构信息

Division of Paleopathology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Via Roma 57, Pisa, Italy.

Division of Paleopathology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Via Roma 57, Pisa, Italy; Laboratory of Physical Anthropology, Department of Public Health and Pediatric Sciences, University of Turin, C.so Galileo Galilei, 22, Turin, Italy.

出版信息

Int J Paleopathol. 2013 Jun;3(2):134-137. doi: 10.1016/j.ijpp.2013.05.005. Epub 2013 Jun 21.

DOI:10.1016/j.ijpp.2013.05.005

PMID:29539313

Abstract

The skeleton of a 9- to 10-year-old child showing a case of skull malformation due to premature bilateral closure of the coronal suture was encountered during the excavation of a Sardinian plague cemetery ("Lo Quarter") dating to the 1582-1583 Alghero plague outbreak. The skull is deformed, with increased bi-parietal diameter, marked frontal and parietal bosses, shallow orbits, and a palpable ridge perpendicular to the coronal suture. Digitate impressions are observable on both fronto-parietal regions of the skull's inner table. Since the splanchnocranium has not preserved, it is impossible to verify if facial anomalies might have been present. Although the cranial appearance might be reminiscent of different genetic syndromes, the absence of obvious hand and feet anomalies is a hallmark for non-syndromic brachycephaly.

摘要

在挖掘一处可追溯至1582 - 1583年阿尔盖罗鼠疫爆发时期的撒丁岛鼠疫公墓（“洛区”）时，发现了一名9至10岁儿童的骨骼，该儿童因冠状缝过早双侧闭合而出现颅骨畸形。颅骨变形，双顶径增大，额部和顶部有明显隆起，眼眶浅，且有一条垂直于冠状缝的可触及嵴。在颅骨内板的额顶区域均可观察到指状压痕。由于脏颅未保存下来，无法证实是否可能存在面部异常。尽管颅骨外观可能使人联想到不同的遗传综合征，但手部和足部无明显异常是非综合征性短头畸形的一个标志。