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自发性早产与子痫前期胎盘组织中HLA-G基因3'非翻译区单核苷酸多态性的比较。

Comparison of single nucleotide polymorphisms in the 3' untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia.

作者信息

Lee Ji Young, Kim Hyun Mi, Kim Mi Ju, Cha Hyun-Hwa, Seong Won Joon

机构信息

Department of Obstetrics and Gynecology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea.

出版信息

BMC Res Notes. 2018 Mar 14;11(1):176. doi: 10.1186/s13104-018-3280-2.

DOI:10.1186/s13104-018-3280-2
PMID:29540242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5853103/
Abstract

OBJECTIVE

To compare single nucleotide polymorphisms (SNPs) in the 3'-untranslated region (3'UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies.

RESULTS

Placental samples matched for gestational age were obtained from 20 cases of spontaneous preterm births and 19 cases of preeclampsia. Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3'UTR region of HLA-G was amplified via polymerase chain reaction. Nine SNPs were analyzed by direct Sanger sequencing. There was no significant difference in gestational age at delivery or birth weight between two groups. And there were no significant differences in the allele and phenotype frequencies between two groups.

摘要

目的

比较自然早产和子痫前期妊娠胎盘组织中人白细胞抗原（HLA）-G基因3'非翻译区（3'UTR）的单核苷酸多态性（SNP）。

结果

收集20例自然早产和19例子痫前期患者与孕周匹配的胎盘样本。从胎盘组织中提取基因组脱氧核糖核酸，通过聚合酶链反应扩增HLA-G基因的3'UTR区域。采用直接桑格测序法分析9个SNP。两组间分娩时的孕周和出生体重无显著差异。两组间等位基因和表型频率也无显著差异。

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