San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy.
Hum Immunol. 2013 Apr;74(4):406-11. doi: 10.1016/j.humimm.2012.11.031. Epub 2012 Dec 10.
Multiple mechanisms underlie the surprising willingness of mothers to tolerate the semi-allogeneic fetal tissues during pregnancy. Chief among these is the expression of the HLA-G molecules that has been largely demonstrated to be responsible for reprogramming the local maternal immune response towards tolerance. We recently identified a subset of tolerogenic dendritic cells, DC-10 that secrete high amounts of IL-10 and express high levels of HLA-G and its ligand ILT4. DC-10 are present in the peripheral blood and are essential in inducing adaptive regulatory T cells. We investigated the presence of DC-10 and HLA-G-expressing CD4(+) T cells in human decidua in the first trimester of pregnancy. Results showed that these cells are highly represented in human decidua as compared to the peripheral blood. This is the first report describing decidual DC-10 and CD4(+)HLA-G(+) T cells, strongly suggesting that they may accumulate or be induced at the fetal maternal interface to promote tolerance.
多种机制导致母亲在怀孕期间对胎儿组织的半同种异体具有惊人的耐受性。其中主要的机制是 HLA-G 分子的表达，大量研究表明 HLA-G 分子负责重新编程局部母体免疫反应向耐受方向发展。我们最近发现了一组具有免疫耐受特性的树突状细胞（DC-10），它们分泌大量的白细胞介素-10（IL-10），并表达高水平的 HLA-G 和其配体 ILT4。DC-10 存在于外周血中，在诱导适应性调节性 T 细胞中起关键作用。我们研究了人类妊娠早期蜕膜中 DC-10 和表达 HLA-G 的 CD4(+)T 细胞的存在情况。结果表明，与外周血相比，这些细胞在人类蜕膜中高度表达。这是首次描述蜕膜中的 DC-10 和 CD4(+)HLA-G(+)T 细胞的报告，强烈表明它们可能在胎儿母体界面处聚集或被诱导，以促进耐受。
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