Tianjin State Key Laboratory of Modern Chinese Medicine, Pharmacology of Traditional Chinese Medicine Formulae, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China.
Fitoterapia. 2018 Jun;127:293-300. doi: 10.1016/j.fitote.2018.03.004. Epub 2018 Mar 11.
Six new cardenolides (1-6), including three 14-hydroxylated cardenolides and three 14-carbonylated cardenolides were isolated from the dried aerial parts of Nerium oleander Linn in addition to twenty-seven known compounds (7-33). Their structures were elucidated on the basis of extensive spectroscopic evidences and single-crystal X-ray diffraction analysis. Compounds 1, 4, 7-10 and 13 exhibited significant cytotoxicity against four colon cancer cell lines (HCT116, HT29, SW620, RKO), one gastric cancer cell line (GT) and one cervical cancer cell line (HeLa) in vitro.
从夹竹桃科植物垂花夹竹桃的干燥地上部分中分离得到了 6 个新的强心苷（1-6），包括 3 个 14-羟基强心苷和 3 个 14-羰基强心苷，此外还有 27 个已知化合物（7-33）。基于广泛的光谱证据和单晶 X 射线衍射分析，确定了它们的结构。化合物 1、4、7-10 和 13 对体外培养的 4 种结肠癌细胞系（HCT116、HT29、SW620、RKO）、1 种胃癌细胞系（GT）和 1 种宫颈癌细胞系（HeLa）表现出显著的细胞毒性。
