心房利钠肽与肺动脉压和心输出量相关。

Atrial natriuretic peptide correlates with pulmonary arterial pressure and cardiac output.

作者信息

Naruse K, Naruse M, Honda T, Obana K, Sakurai H, Demura H, Hirosawa K, Inagami T, Shizume K

出版信息

Peptides. 1987 Mar-Apr;8(2):285-90. doi: 10.1016/0196-9781(87)90103-3.

Abstract

Correlations between plasma atrial natriuretic polypeptide (ANP) levels and hemodynamic parameters were studied in the central circulation of 12 patients with angina pectoris. The average plasma ANP level determined in the aorta was found to be 619 +/- 140 pg/ml. The plasma ANP levels showed a significant positive correlation with mean pulmonary arterial (PA) pressure, right ventricular pressure, and with cardiac index. In contrast, there was no significant correlation between plasma ANP levels and other hemodynamic variables including atrial pressure. These results suggest that hemodynamics other than the atrial pressure may have some role in modulating ANP secretion in certain pathological states.

摘要

在12例心绞痛患者的中心循环中研究了血浆心钠素（ANP）水平与血流动力学参数之间的相关性。测定主动脉中的平均血浆ANP水平为619±140 pg/ml。血浆ANP水平与平均肺动脉（PA）压、右心室压力以及心脏指数呈显著正相关。相比之下，血浆ANP水平与包括心房压力在内的其他血流动力学变量之间无显著相关性。这些结果表明，在某些病理状态下，除心房压力外的血流动力学因素可能在调节ANP分泌中起一定作用。