日本医科大学千叶北总医院引入结合疫苗前后儿童侵袭性细菌疾病的发病率
The Incidence of Pediatric Invasive Bacterial Diseases in Nippon Medical School Chiba Hokusoh Hospital before and after the Introduction of Conjugate Vaccines.
作者信息
Sano Toumi, Suzuki Tamaho, Nishigori Ayako, Miyatake Chiharu, Koizumi Shinya, Kaizu Kiyohiko, Fujita Atsushi, Kamisago Mitsuhiro, Chang Bin, Ishiwada Naruhiko, Asano Takeshi
机构信息
Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital.
Department of Bacteriology I, National Institute of Infectious Diseases.
出版信息
J Nippon Med Sch. 2018;85(1):34-38. doi: 10.1272/jnms.2018_85-5.
The introduction of the Haemophilus influenzae type b (Hib) vaccine and the 7-valent pneumococcal conjugate vaccine (PCV7) has led to dramatic reductions in cases of invasive H. influenzae disease and invasive pneumococcal disease (IPD). After the introduction of the PCV7 and the 13-valent pneumococcal conjugate vaccine (PCV13), the number of children with IPD markedly decreased in our hospital. However, since 2015, three children with IPD have been admitted to our hospital. We analyzed the serotype, multilocus sequence type, and antimicrobial susceptibility of Streptococcus pneumoniae strains isolated in these newly diagnosed cases. The strains were serotypes 7F and 12F. In addition, we analyzed the incidence of invasive bacterial disease before and after the introduction of conjugate vaccines and found no change in the incidences. We found that cases of IPD and invasive H. influenzae disease clearly decreased following the introduction of the PCV7, the PCV13, and the Hib vaccine, as well as disease caused by antibiotic-resistant strains.
b型流感嗜血杆菌（Hib）疫苗和7价肺炎球菌结合疫苗（PCV7）的引入，已使侵袭性流感嗜血杆菌病和侵袭性肺炎球菌病（IPD）的病例数大幅减少。在引入PCV7和13价肺炎球菌结合疫苗（PCV13）后，我院IPD患儿数量显著减少。然而，自2015年以来，有3例IPD患儿入住我院。我们分析了这些新诊断病例中分离出的肺炎链球菌菌株的血清型、多位点序列类型和抗菌药敏情况。这些菌株为7F和12F血清型。此外，我们分析了结合疫苗引入前后侵袭性细菌病的发病率，发现发病率没有变化。我们发现，引入PCV7、PCV13和Hib疫苗后，IPD和侵袭性流感嗜血杆菌病的病例明显减少，由抗生素耐药菌株引起的疾病也明显减少。
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