VKORC1 序列变异与抗凝血灭鼠剂在爱尔兰的挪威鼠和小家鼠种群中的抗性有关。
VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus.
机构信息
Molecular Virology Laboratory, Department of Agriculture, Food and the Marine Laboratories, Backweston Campus, Celbridge, Co Kildare, Ireland.
Chairman, Campaign for Responsible Rodenticide Use Ireland CLG, c/o Glendine, 36 Ludford Drive, Dundrum, Dublin 16, Ireland.
出版信息
Sci Rep. 2018 Mar 14;8(1):4535. doi: 10.1038/s41598-018-22815-7.
While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed, indicative of an absence, or low prevalence, of resistance in rats in at least the Eastern region of the island of Ireland. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland.
虽然在许多欧洲的挪威鼠和家鼠种群中已知存在对抗凝血灭鼠剂的抗性，但迄今为止，爱尔兰还没有关于这种抗性发生的数据。在分析的 65 个挪威鼠样本中没有发现抗性的遗传证据，这表明在爱尔兰岛的东部地区，老鼠的抗性至少不存在或很少存在。证实了与家鼠对抗凝血灭鼠剂抗性相关的两种最常见氨基酸替换的存在：亮氨酸 128 丝氨酸和酪氨酸 139 半胱氨酸。这两种突变的存在表明，在爱尔兰岛的东部地区，家鼠对抗凝血灭鼠剂的抗性已经发生。
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