Zollikofer C L, Redha F H, Bruhlmann W F, Uhlschmid G K, Vlodaver Z, Castaneda-Zuniga W R, Amplatz K
Radiology. 1987 Jul;164(1):145-9. doi: 10.1148/radiology.164.1.2954183.
To investigate the acute and long-term effects on the vasa vasorum after massive overdilation, canine aortic segments were dilated with Gruentzig balloon catheters to more than 100% over normal size. In the acute study, the significant lumen increase was the result of intimal and medial rupture with stretching and thinning of the adventitia. In these areas, the vasa vasorum were stretched and severed, causing adventitial hemorrhage. In the chronic study, areas of previous subtotal wall rupture with adventitial thinning were repaired by scar tissue. This repair included formation of a neomedia, hyperplasia of the adventitia, and proliferation of the vasa vasorum. No progression of luminal dilatation was seen. This study showed that in subtotal aortic wall rupture, even a severely damaged adventitia is capable of preserving the lumen from further dilatation and rupture until healing. Blood flow to the damaged vessel wall was reestablished by revascularization via capillary budding in the aortic wall.
为研究大规模过度扩张后对滋养血管的急性和长期影响，用Gruentzig球囊导管将犬主动脉段扩张至超过正常尺寸的100%以上。在急性研究中，管腔显著增大是内膜和中膜破裂以及外膜拉伸变薄的结果。在这些区域，滋养血管被拉伸并切断，导致外膜出血。在慢性研究中，先前存在外膜变薄的部分管壁破裂区域由瘢痕组织修复。这种修复包括新中膜的形成、外膜增生和滋养血管增殖。未见管腔扩张进展。该研究表明，在主动脉壁部分破裂时，即使外膜严重受损，也能够保护管腔不再进一步扩张和破裂直至愈合。通过主动脉壁内毛细血管芽生实现血管再生，从而重新建立受损血管壁的血流。
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