Sedan R, Peragut J C, Pontier R, Pomane C
Ann Anesthesiol Fr. 1978;19(5):449-54.
This report concerns the current status of the results of intraencephalic implantations carried out up to the present time in man with the aim of relieving certain forms of chronic pain. It places little emphasis upon the neuro-physiological basis of these implantations, which have been studied at length during previous reports. After presenting the overall results of operations carried out in the world up until September 1967, a critical study is undertaken: 1--In relation to the targets (Postero-Lateral Ventral Nucleus, posterior arm of the internal capsule, para-ventricular thalamic grey matter). 2--In relation to etiologies, both analytically (syndrome) by syndrome as well as in terms of synthesis (excess of pain perception-deafferentation). 3--In terms of various factors, such as: --technical requirements; --side ffects; --duration of "post effect" (residual analgesia after stimulation); --parallel action of drugs. Conclusions are drawn concerning future perspectives of this technique.
本报告涉及目前为止人类进行脑内植入以缓解某些形式的慢性疼痛的结果现状。报告很少强调这些植入的神经生理学基础,在之前的报告中已对此进行了详尽研究。在呈现截至1967年9月在世界范围内开展的手术的总体结果之后,进行了一项批判性研究:1. 关于靶点(后外侧腹侧核、内囊后肢、丘脑室旁灰质)。2. 关于病因,既按综合征逐一分析,也从综合角度(痛觉过敏-去传入)进行分析。3. 就各种因素而言,例如:——技术要求;——副作用;——“后效应”持续时间(刺激后的残余镇痛);——药物的协同作用。得出了关于该技术未来前景的结论。